Peptide tier list
Peptide tier list S-F.
A practical S-F ranking of peptides by research interest, evidence quality, usefulness, and risk profile.
Approved or dominant evidence
The strongest evidence: approvals, phase 3 data, or a long track record.
7 entriesSemaglutideGLP-1 for weight loss and glucose control.TirzepatideGIP/GLP-1 for high-efficacy weight loss.RetatrutideTriple agonist for major weight-loss outcomes.TesamorelinVisceral-fat reduction through GH-axis signaling.HGHGrowth hormone replacement and body-composition effects.HCGFertility and testosterone-support hormone.GHK-CuSkin repair, hair, collagen, and copper-peptide research.
Strong data or narrow approvals
Strong trials or labels, though real-world use may go wider than the label.
12 entriesBPC-157Tendon, gut, and soft-tissue recovery research.TB-500 (TB4)Mobility, tissue repair, and recovery research.CJC-1295Longer-acting GH-release support.IpamorelinGentler GH secretagogue for recovery and sleep.SermorelinGHRH analog for GH-release support.PT-141Libido and sexual-arousal peptide.Melanotan-IITanning and melanocortin-effect research.KLOWRepair, skin, and immune-support blend.GLOWSkin, collagen, and recovery blend.CJC + Ipamorelin blendCombined GH-release support stack.BPC + TB blendPopular repair and recovery stack.SS-31Mitochondrial and cellular-energy support research.
Real science, mixed results
The mechanism makes sense, but outcomes vary by person and dose.
8 entriesSemaxFocus, cognition, and neuroprotection research.SelankCalm, anxiety, and mood-support research.CagriSemaAmylin plus GLP-1 weight-loss stack.Kisspeptin-10Reproductive-hormone signaling research.OxytocinBonding, social, and mood hormone.MOTS-CMitochondrial metabolism and exercise-mimetic research.KPVGut, skin, and inflammation-support peptide.NAD+Cellular-energy and redox support.
Off-label or thin data
Plausible use cases with smaller studies, niche uses, or limited data.
11 entriesEpithalonLongevity and circadian-aging research.PinealonCognitive and healthy-aging research.DSIPSleep and stress-recovery research.Thymosin alpha-1Immune modulation and infection-support research.GonadorelinGnRH signaling and hormone diagnostics.TriptorelinGnRH analog for hormone suppression.Melanotan IPhotoprotection and pigmentation pathway research.AHK-CuHair and skin copper-peptide research.TB-500 fragFormal 7-aa thymosin beta-4 17-23 fragment.HGH frag 176-191Fat-metabolism GH-fragment research.5-amino-1mqNNMT and metabolic research compound.
Hype outruns data
Weak results, absorption issues, or side effects limit the upside.
6 entriesDihexaHGF-mimetic cognition and synapse research.Snap-8Topical wrinkle and expression-line cosmetic.GlutathioneAntioxidant, redox, and skin-tone support.GHRP-2GH-release and ghrelin-receptor research.GHRP-6GH release and appetite-stimulation research.AOD 9604GH-fragment research around fat metabolism.
Serious safety concerns
Documented risks where the downside outweighs the benefit.
2 entries